GNC Research Expertise

Specific Areas of Research Expertise

  • Development and validation of novel biomaterial-based technologies for treating neurological disorders
  • Stem cell technologies, including adult stem cells and induced pluripotent stem cells, and the application of these technologies to brain and spinal cord repair
  • The role of neuroinflammation, the endocannabinoid system, endoplasmic reticulum stress, neurotrophic factors, heat shock proteins and histone deacetylase complex in neurological and psychiatric disorders
  • Pain research from bench to bedside through the Centre for Pain Research
  • Development and validation of novel and highly-relevant animal models of neurological and psychiatric disorders
  • Expertise in behavioural evaluation of motor, cognitive, affective and sensory function in animal models and in patients
  • Clinical neuroimaging: structural, diffusion and functional MRI
  • SNP genotyping, genome-wide association studies, nextgeneration sequencing, copy number variant analysis pertaining to schizophrenia and other nervous system disorders
  • Cognitive neuroscience
  • Psychological (e.g. cognitive behavioural) interventions for improved management of neurological and psychiatric disorders

Technical Capabilities

  • Clinical neuroimaging: MRI and PET
  • Clinical EEG/EMG neurophysiology
  • Neuropsychological and clinical assessment of cognition
  • Clinical and preclinical genomics: genotyping and next-generation sequencing
  • Generation of human pluripotent stem cells (iPSc)
  • Preclinical disease models: anxiety, autism, depression, multiple sclerosis, Parkinson’s disease, pain, spinal cord injury, stress, stroke
  • Preclinical behavioural neuroscience
  • In vitro disease models: Huntington’s disease, neurodegeneration, neuroinflammation, Parkinson’s disease, stroke
  • In vivo microdialysis
  • Proteomics/lipidomics: mass spectrometry
  • Microscopy (incl. electron and confocal), histology, autoradiography and neurostereology
  • Cell/Enzyme based assays
  • Molecular biology (e.g. Western blot, RT-qPCR)
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